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1. OverView:

Exemestane lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Exemestane is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after surgery, radiation, or other cancer medications have been tried without success.

Exemestane may also be used for purposes not listed in this medication guide.

2. How does this drug work:

Exemestane is part of a general group of drugs called aromatase inhibitors. Normally in the body, some of the androgens (male hormones) that are made by the adrenal glands are converted to estrogen by an enzyme in fat tissue called aromatase. This drug blocks aromatase so that estrogen isn’t formed that way. This lowers estrogen levels in women who do not have functioning ovaries. This drug doesn’t affect estrogen production from the ovaries, so has little effect on estrogen levels in women whose ovaries are working. If estrogen levels are lowered, breast cancers that require estrogen to grow may stop growing or even shrink.

3. Exemestane dosing information:

1. Usual Adult Dose for Breast Cancer:

For early and advanced breast cancer:

Recommended dose: 25 mg orally once daily after a meal.

2. In postmenopausal women with early breast cancer who have been treated with two to three years of tamoxifen, treatment with exemestane should continue in the absence of recurrence or contralateral breast cancer until completion of five years of adjuvant endocrine therapy.

3. For patients with advanced breast cancer, treatment with exemestane should continue until tumor progression is evident.

4. What other drugs will affect exemestane?

Other drugs may interact with exemestane, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.