1. OverView:
Megestrol acetate (INN, USAN, BAN, JAN; sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimes abbreviated as MGA or MA, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.
2. Application:
Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.
In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.
3. Usage:
Megestrol acetate is available as 5 mg, 20 mg and 40 mg tablets and in oral suspensions of 125 mg/ml and 40 mg/ml. It is used at a dose of 5 mg in combination with an estrogen for contraception. Appetite stimulation is achieved with doses ranging from 400 mg to 800 mg a day. Doses used to treat cancer usually range from 40 mg to 320 mg.
4. Side effects:
The most common side effect of megestrol acetate is weight gain. Other side effects may include nausea, vomiting, impotence, edema, breakthrough bleeding, and shortness of breath. Rare and more severe side effects may include thrombophlebitis and pulmonary embolism. It may also cause glucocorticoid-related adverse effects such as adrenal insufficiency in some individuals and/or cases (especially if the medication is suddenly discontinued following prolonged use).
5. COA:
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Test Items
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Specification
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Test Results
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Appearance
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White to creamy white crystalline powder
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White crystalline powder
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Identification
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IR
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Complies
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Completeness of solution
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Meets the requirements.500mg being dissolved in 10ml of acetone
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Complies
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Solubility
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Insoluble in water, sparingly soluble in alcohol. Slightly soluble in ether and in fixed oils, soluble in acetone; very soluble in chloroform.
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Complies
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Melting range
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213°C~220°C
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217°C
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Specific optical rotation
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+8.8°~ +12.0°
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+11.6°
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Water
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≤0.5%
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0.1%
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Residue roration
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≤0.2%
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0.06
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Heavy metals
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≤0.002%
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Complies
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Assay
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97.0%~103.0%
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99.6%
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Residual solvents
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Methanol≤1000ppm
Ethanol≤1000ppm
Methylene chloride≤500ppm
Tetrahydrofuran≤300ppm
Benzene≤2ppm
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74ppm
39ppm
28ppm
ND
ND
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6. Competitive Advantage:
(1) Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.
Payment method: T/T, Western union, Moneygram
(2) Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
(3) Top quality. High quality guarenteed, once any problem is found, the package would be reshipped for you .
(4) Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
(5) We have stock, so we can delivery quickly at the very day when receive the payment.
(6) Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.
(7) A discount would be given when you make a large order.
Delivery Details:We have the special way can ship 0.01kg to 3.5kg products at a time. We can offer the melting powder into liquid service.And ship the liquid in the special bottles. According to your request and the quantity what you buy, we have several packaging methods.
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