1. Description:
Levonorgestrel (or l-norgestrel or D-norgestrel) (Plan B, Next Choice, Postinor, "the morning after pill," and others) is a second generation progestin (synthetic progestogen) used as an active ingredient in some hormonal contraceptives, includingcombined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems, contraceptive implants, and hormone replacement therapy.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basichealth system.
2. Usage & Dosing:
(1) Oral contraception:
At low doses, levonorgestrel is used in monophasicand triphasicformulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250μg, and triphasic doses of 50μg/75μg/125μg.
At very low daily dose of 30μg, levonorgestrel is used in some progestogen only pillformulations.
(2) Emergency contraception:
Levonorgestrel is used in emergency contraceptive pills(ECPs), both in a combined Yuzpe regimenwhich includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5mg (as a single dose or as two 0.75mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.
The primary mechanism of action of levonorgestrel as a progestogen-only emergency contraceptive pill is, according to FIGO, to prevent fertilization by inhibition of ovulation. The International Federation of Gynecology and Obstetrics(FIGO) has issued a statement that: "review of the evidence suggests that LNG [levonorgestreol] ECPs cannot prevent implantation of a fertilized egg. Language on implantation should not be included in LNG ECP product labeling." In June 2012, a New York Timeseditorial called on the Food and Drug Administration(FDA) to remove from the label the unsupported suggestion that levonorgestrel emergency contraceptive pills inhibit implantation. In November 2013, the European Medicines Agency(EMA) approved a change to the label for HRA Pharma's NorLevo saying it cannot prevent implantation of a fertilized egg. In November 2013, the EMA also approved a change to the label for HRA Pharma's NorLevo saying: "In clinical trials, contraceptive efficacy was reduced in women weighing 75 kg [165 pounds] or more, and levonorgestrel was not effective in women who weighed more than 80 kg [176 pounds]." In November 2013 and January 2014, the FDA and the EMA said they were reviewing whether increased weight and body mass index(BMI) reduce the efficacy of emergency contraceptives.
Levonorgestrel is also used in Intrauterine system, Contraceptive implants and Hormone replacement therapy.
3. COA:
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Items
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Specification
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Results
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Description
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White or practically white crystalline powder
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White crystalline powder
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Specific Rotation
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30°~-35°
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32°
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Melting Range
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232~239°C, and melting range is not more then 4°C
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234~238°C
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identification
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It complies with the test for specific optical rotation and melting point
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Conforms
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Infrared absorption spectrophotometry should be consistent with levonorgestrel CRS
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Conforms
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Loss on drying
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≤0.5%
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0.20%
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Residue on ignition
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≤0.3%
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0.07%
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Limit of Ethynyl Group
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7.81%~8.18%
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7.92%
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Related substances
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Single impurity ≤0.5%
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single impurity<0.5%
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Total Impurities ≤2.0%
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Total impurities<2.0%
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Organic Volatile impurties
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Ethanol ≤5000ppm
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1200ppm
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Assay
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The product complies with specification in USP34
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Particle Size
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D(0.9)<10μm
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Storage Condition
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Sealed, protect from light
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4. Competitive Advantage:
(1) Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.
Payment method: T/T, Western union, Moneygram
(2) Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
(3) Top quality. High quality guarenteed, once any problem is found, the package would be reshipped for you .
(4) Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
(5) We have stock, so we can delivery quickly at the very day when receive the payment.
(6) Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.
(7) A discount would be given when you make a large order.
Delivery Details:We have the special way can ship 0.01kg to 3.5kg products at a time. We can offer the melting powder into liquid service.And ship the liquid in the special bottles. According to your request and the quantity what you buy, we have several packaging methods.
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