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HomeProductsGlucocorticoid Steroids

Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne

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Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne

Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne supplier Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne supplier

Large Image :  Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne

Product Details:

Place of Origin:China
Brand Name:SMQ
Certification:ISO9001,KOSHER
Model Number:4759-48-2

Payment & Shipping Terms:

Minimum Order Quantity:100g
Price:Negotiable
Packaging Details:as your requirement
Delivery Time:within 4-7 working days after payment
Payment Terms:Western Union, MoneyGram, T/T
Supply Ability:100kg/month
Detailed Product Description
Appearance: Orange Crystal Powder Phone: 86-18038176801
Email: Maisie@ycphar.com Skype: Mercyawu01

Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne

 


 
Isotretinoin of Details:

 

Product Name Isotretinoin
Synonyms 13-cis-retinoic acid; 13-cis-vitamin a acid; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid; (13cis)-15-oxidoretinal
Molecular Formula C20H27O2
Molecular Weight 299.4277
InChI

InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20

(18,4)

5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14-

CAS Registry Number 4759-48-2
EINECS 225-296-0
Molecular Structure 4759-48-2 isotretinoin
 
Melting point 174-177℃
Boiling point 462.8°C at 760 mmHg
Flash point 350.6°C
Water solubility insoluble
Vapour Pressure 7.55E-10mmHg at 25°C
Assay 99%
Appearance Orange Crystal Powder

 
 

Description of Isotretinoin: 
 

Isotretinoin, (also known as 13-cis retinoic acid) first marketed as Accutane by Hoffmann-La Roche, is a medication primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and can be used in the treatment of brain, pancreatic and other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. 
Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include: Muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development. 
In the United States a special procedure is required to obtain the pharmaceutical. In most other countries a consent form is required which explains these risks. Women taking isotretinoin must not get pregnant during, and for 1 month after isotretinoin therapy. Sexual abstinence, or effective contraception is mandatory during this period. Barrier methods by themselves (such as condoms) are not considered adequate due to the unacceptable failure rates of approximately 3%. Women who fall pregnant whilst on isotretinoin therapy are generally counselled to have a termination. Isotretinoin has no effect on male reproduction. 
In 2009, Roche decided to remove Accutane from the US market after juries had awarded millions of dollars in damages to former Accutane users over inflammatory bowel disease claims. Other common brands are Roaccutane (Hoffman-La Roche, known as Accutane in the United States before July 2009), Amnesteem (Mylan), Claravis (Teva), Absorica (Ranbaxy), Isotroin (Cipla), and Epuris (Cipher). 

Application of Isotretinoin: 
 

Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. Acne treatment usually begins with topical retinoids (e. G. Tretinoin, adapalene), in combination with topical antibiotics (e. G. Clindamycin, erythromycin) or antiseptics (e. G. Benzoyl peroxide-containing preparations), followed by oral antibiotics (e. G. Doxycycline or minocycline). In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications. 
In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation. 

Specification of Isotretinoin:
 
 
Test Item Standard Test Results
Appearance White or alomost white crystalline powder  white crystalline powder
Loss on drying <0.5% 0.24%
Optical rotation +69~+74 73.3
Assay 97--103% 99%
Free acid 0.5%max 0.21%
Conclusion The aboye product conforms analysis standard Conform
 

 
Orange Crystal Glucocorticoid Steroids CAS 4759-48-2 Neovitaminaacid Isotretinoin for Treatment Acne
 
 
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