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HomeProductsAnti Estrogen Steroids

Tibolone Restore Oestrogen and Progestogen Estrogen Steroids white crystalline powder

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Tibolone Restore Oestrogen and Progestogen Estrogen Steroids white crystalline powder

Large Image :  Tibolone Restore Oestrogen and Progestogen Estrogen Steroids white crystalline powder

Product Details:

Place of Origin:China
Certification:ISO9001; ISO14000

Payment & Shipping Terms:

Minimum Order Quantity:100g
Price:USD2392/100g
Packaging Details:100g/bag, 500g/bag, 1kg/bag
Delivery Time:1-3 work days
Payment Terms:T/T, Western Union, MoneyGram
Supply Ability:100kg/month
Detailed Product Description
CAS:: 5630-53-5 Assay:: 98%

 

Steroid Tibolone Restore Oestrogen and Progestogen

 

Basic Description:

 

Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha.It is used mainly for treatment of endometriosis,as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile.It has also been investigated as a possible treatment for female sexual dysfunction.

 

Applications:

 

Although the menopause is a generic physiologic event, its biology is variable and specific to a given individual. Genetically determined distribution and polymorphism of relevant hormone receptors, enzymes, and various cofactors are the biologic mechanisms controlling an individual's clinical response to endogenous and prescribed hormones. Advances in molecular biology have led to the development of newer pharmacologic agents that are tailored to meet specific therapeutic objectives, based on the hormonal biology of relevant organs. Tibolone, an analogue of the progestin, norethynodrel, is a drug with tissue-specific effects on receptors and enzymes that influences the synthesis and metabolism of endogenous estrogen, progesterone, and androgen. This is achieved via the intestinal bioconversion of tibolone into metabolites that have tissue-specific agonistic and/or antagonistic estrogenic (3alpha and 3beta hydroxytibolone) and progestogenic/androgenic (delta4 tibolone) properties.

 

The postmenopausal synthesis and metabolism of estrogen and androgen are briefly reviewed with particular reference to sex steroid activity in various target organs. On the basis of this hormonal physiology, the clinical utility of tibolone is reviewed as a therapeutic agent for the treatment of the symptomatic menopause. The effects of tibolone on bone health and osteoporosis, cardiovascular disease, the breast, and the endometrium are summarized, and its role in clinical practice is reviewed.

 

 

Tag:Tibolone;LIVIELLA;LIVIAL;Estrogen Powders;

 

 

 

Product Name

Tibolone

Synonyms

-TIBOLONE; LIVIELLA; LIVIAL; 5(10)-ESTREN-7-ALPHA-METHYL-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE; (7A,17A)-17-HYDROXY-7-METHYL-19-NORPREGN-5(10)-EN-20-YL-3-ONE; 17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one; 17ALPHA-HYDROXY-7ALPHA-METHYL-19-NORPREGN-5(10)-EN-20-YN-3-ONE; 19-NORPREGN-5(10)-EN-20-YN-3-ONE,17-HYDROXY-7-METHYL-, (7A,17A)-; (7alpha,8xi,13xi,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)-en-3-one; (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)-en-3-one

Molecular Formula

C21H28O2

Molecular Weight

312.4458

InChI

InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1

CAS Registry Number

5630-53-5

EINECS

227-069-1

Molecular Structure

Tibolone Restore Oestrogen and Progestogen Estrogen Steroids white crystalline powder

Density

1.13g/cm3

Boiling point

447.4°C at 760 mmHg

Refractive index

1.57

Flash point

190.6°C

Vapour Pressure

6.96E-10mmHg at 25°C

Assay

98%

Appearance

White or white crystalline powder

 

 

Usage:

  • Prevention of bone fractures in women
  • Treatment of symptoms associated with low levels of the hormone oestrogen in women.

 

 

Our advantages:

1. High quality products with competitive prices.

2. We provide professional service.

3. Enough stock and Fast delivery.

4. We asure safe and effective shipping method.

5. Fast response to any emails or problems.

 

Available tracking numbers to USA:

EE689150169CN

EE689150084CN

EE750056148CN

EE689151059CN

EA211716874HK

Contact Details
Shenzhen Haiwen Biotechnology Co.,Ltd

Contact Person: Mrs. Lisa

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