Clomifene Citrate Clomid Anti Estrogen Steroid Hormone Serophene Clomphid

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1. What is clomifene citrate:
Clomifene citrate is a drug treatment that stimulates your ovaries to release eggs. 

Ovulation stimulation using clomifene citrate is a well-established, effective treatment. Clomifene citrate is the most widely used of all fertility drugs. 

Other drugs that may be used to treat ovulation disorders include metformin and bromocriptine.
2. What's the success rate of clomifene citrate:
About 70 per cent of women will ovulate in response to a fairly low dose of clomifene citrate. Of those who ovulate, about 40 per cent will become pregnant. 

Other factors that can affect the pregnancy rate include: 
the time in your cycle that you have sex
your age and weight
the count, shape, speed and motility (ability to move) of your partner's sperm

A low dose of clomifene may not be enough. Your doctor may increase the dose to help you conceive.

Studies suggest that about 29 per cent of women who start taking the drug go on to have a live birth.

3. How does clomifene citrate work:
Clomifene citrate blocks the effect of the hormone oestrogen in your body. This blocking effect tricks your body into bumping up levels of two other hormones that are essential for ovulation. These two other hormones are: 
(1) follicle-stimulating hormone (FSH)
(2) luteinising hormone (LH)
FSH causes the eggs in your ovaries to ripen, ready for release. LH triggers the release of one or more mature eggs from the ovary follicles. The egg or eggs then move down into one of your fallopian tubes.

4. How long will I have to take clomifene citrate for:
You usually take clomifene in pill form for five days early in your cycle, for up to six months at a time. A low dose of 50 mg is often used to start with. 

(1) If you have regular cycles, you'll start taking the pills within five days of your period starting, preferably on about day two. 
(2) If you're not menstruating at all or if your cycle is very irregular, your doctor will check that you're not pregnant. She'll then give you a synthetic version of the hormone progesterone, a progestogen called Provera. 
(3) Progesterone works with oestrogen to keep your reproductive cycle regular. Provera will re-establish your periods. Once you're having periods, you can then start taking clomifene citrate. 
(4) Ovulation generally occurs between five days and nine days after you've taken your last pill. Your fertility specialist may monitor your ovaries using ultrasound, at least during the first cycle. She'll look to see how your ovaries are responding and whether one egg follicle or more is preparing to release a mature egg into one of your fallopian tubes. 
(5) You might ovulate and conceive in the first month of taking clomifene citrate. Or it can take a month or two of drug therapy for you to start ovulating regularly. 
(6) Treatment may be continued for up to six cycles, as this is thought to be long enough to see whether your body is responding to the drug. 

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